Modeling and optimizing the temperature distribution around cancerous tissues during magnetic hyperthermia treatment

In magnetic nanoparticle hyperthermia treatment, the ideal objective is to destroy all tumor cells without any damage to neighboring normal tissues. Thus, the temperature distribution in cancerous tissue and also surrounding healthy tissues should become closer to the desired distribution. In this paper, the temperature distribution is estimated by using a numerical scheme to solve the Penne’s bioheat transfer equation in a bilayered spherical tissue with blood perfusion and metabolism. The accuracy of the present model was justified by comparing with an experimental data and similar analytical schemes. Changing the parameters of cancerous tissue showed that the most effective parameter, to optimize the treatment, is the tissue conductivity. Subsequently, we demonstrated that among different factors influencing the tissue conductivity, the mass fraction of water in the tissue is the main factor. According to mass fraction of water in cancerous tissue, two methods of magnetic nanoparticle hyperthermia treatment was suggested.